Nishijima Y, Koiso K, Nemoto R
Department of Urology, University of Tsukuba.
Nihon Hinyokika Gakkai Zasshi. 1994 Nov;85(11):1636-42. doi: 10.5980/jpnjurol1989.85.1636.
The biology of skeletal metastasis is poorly understood. In order to establish an animal model of spinal bone metastasis, we injected MBT-2 tumor cells into the tail vein of C3H/He mice while the inferior vena cava was occluded. By this technique, the tumor cells were transferred into the vertebral plexus. Spinal lesions developed in 12 of 15 (80%) experimental mice and in none of the control mice. All bone lesions resulted in local bone destruction. The predominant site of bone metastasis was lumbarvertebrae; other affected sites were thrpelvis and coccyges. This model should be of value in understanding the pathogenesis of spinal bone metastasis and in studying the effects of various agents on the prevention and control of spinal lesions.
骨骼转移的生物学机制目前仍知之甚少。为了建立脊柱骨转移的动物模型，我们在阻断下腔静脉的同时，将MBT - 2肿瘤细胞注入C3H/He小鼠的尾静脉。通过这种技术，肿瘤细胞转移至椎静脉丛。15只实验小鼠中有12只（80%）出现了脊柱病变，而对照小鼠均未出现。所有骨病变均导致局部骨质破坏。骨转移的主要部位是腰椎；其他受累部位是骨盆和尾骨。该模型对于理解脊柱骨转移的发病机制以及研究各种药物对脊柱病变的预防和控制效果具有重要价值。
