Saito M, Saito S, Nakagawa T, Ichijo M, Motoyoshi K
Department of Obstetrics and Gynecology, Osaka Prefectural Habikino Hospital, Japan.
Asia Oceania J Obstet Gynaecol. 1992 Dec;18(4):355-61. doi: 10.1111/j.1447-0756.1992.tb00331.x.
A large amount of M-CSF and G-CSF exists in human amniotic fluid and both are considered to have some physiological affect on maintaining pregnancy. We therefore examined the source of M-CSF and G-CSF found in the amniotic fluid. The average level of M-CSF in the amniotic fluid of patients without complications was 17.3 +/- 8.5 ng/ml and that of G-CSF 1.85 +/- 1.72 ng/ml, both being high values. In neonatal urine, the average level of M-CSF was also very high, 144.3 +/- 97.0 ng/ml, but that of G-CSF was below the determination limit of 60 pg/ml. Immunohistochemical staining indicated that production of M-CSF and G-CSF was localized in the epithelial cells of fetal membrane. On the basis of the above observations, M-CSF was found to derive from neonatal urine and the epithelial cells of fetal membrane, and G-CSF from the epithelial cells of fetal membrane.
人羊水中存在大量的巨噬细胞集落刺激因子（M-CSF）和粒细胞集落刺激因子（G-CSF），二者被认为对维持妊娠具有一定的生理作用。因此，我们研究了羊水中M-CSF和G-CSF的来源。无并发症患者羊水的M-CSF平均水平为17.3±8.5 ng/ml，G-CSF为1.85±1.72 ng/ml，均为较高水平。在新生儿尿液中，M-CSF的平均水平也非常高，为144.3±97.0 ng/ml，但G-CSF低于60 pg/ml的检测限。免疫组织化学染色表明，M-CSF和G-CSF的产生定位于胎膜上皮细胞。基于上述观察结果，发现M-CSF来源于新生儿尿液和胎膜上皮细胞，而G-CSF来源于胎膜上皮细胞。
