Atahanov S E, Elizarova E P
Cardiology Research Center, Moscow, Russia.
Arzneimittelforschung. 1992 Nov;42(11):1311-3.
Taurine (2-aminoethanesulfonic acid, CAS 107-35-7) is present in high concentrations in platelets. It suppresses bronchial responses to platelet-activating factor (PAF) and inhibits aggregation induced by ADP. In the present experiments human platelet calcium responses to PAF were measured by a fluorescent label "Quin-2" method. Preincubation with 0.01 mol/l of taurine decreased effects of PAF by 250 nmol/l if the initial Ca intracellular response (delta Ca2+) to inductor was more than 400 nmol/l. If the initial response to inductor was less than 150 nmol/l, taurine did not affect the response to inductor if PAF effect was in delta Ca2+ range of 150-400 nmol/l. Hence, some effects of taurine may be ascribed to its modulating influence on secondary Ca2+ messenger.
牛磺酸（2-氨基乙磺酸，CAS 107-35-7）在血小板中含量很高。它可抑制支气管对血小板活化因子（PAF）的反应，并抑制由二磷酸腺苷（ADP）诱导的聚集。在本实验中，通过荧光标记“喹啉-2”法测量人血小板对PAF的钙反应。如果对诱导剂的初始细胞内钙反应（ΔCa2+）超过400 nmol/L，用0.01 mol/L的牛磺酸预孵育可使250 nmol/L的PAF作用降低。如果对诱导剂的初始反应小于150 nmol/L，当PAF作用在ΔCa2+为150 - 400 nmol/L范围内时，牛磺酸不影响对诱导剂的反应。因此，牛磺酸的某些作用可能归因于其对继发性Ca2+信使的调节作用。
