Almazov V A, Gurevich V S, Mikhaĭlova I A, Strel'tsova E N
Biull Eksp Biol Med. 1985 Oct;100(10):398-400.
Effect of taurine (25 mM) on calcium metabolism in human platelets was studied. Ca, Mg-ATPase activity is significantly increased upon addition of 25 mM of taurine to the incubation medium. The activation is absent or reduced in the presence of trifluoroperazine and beta-alanine and after preincubation of platelets with colchicine and verapamil. The rate of ADP (3.5 X 10(-6) M)-induced platelet aggregation is reduced by half upon taurine addition to platelet-rich plasma. The possible role of taurine in intracellular calcium translocation and the following alteration of platelet activity is suggested.
研究了牛磺酸（25 mM）对人血小板钙代谢的影响。向孵育培养基中添加25 mM牛磺酸后，钙、镁 - ATP酶活性显著增加。在存在三氟拉嗪和β - 丙氨酸时，以及血小板先用秋水仙碱和维拉帕米预孵育后，这种激活作用不存在或减弱。向富含血小板的血浆中添加牛磺酸后，ADP（3.5×10⁻⁶ M）诱导的血小板聚集速率降低了一半。提示了牛磺酸在细胞内钙转运以及随后血小板活性改变中的可能作用。
