Lidén S
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Semin Dermatol. 1992 Dec;11(4):275-7.
Topical corticoids remain the mainstay of treatment for mild psoriasis. In recent years certain valuable modifications of this mode of treatment have emerged. Clobetasol propionate was found to induce the highest immediate response if applied as intensive pulse therapy and possibly also to induce longer remissions than other compounds. Once-daily application of betamethasone dipropionate in optimized vehicle and mometasone furoate were at least as effective as repeated applications of several other compounds. There are indications of a dissociation of potency and side effects for mometasone furoate. Thus, corticoid therapy now can be tailored to suit more closely the needs of the patients than was possible previously.
外用皮质类固醇仍然是轻度银屑病治疗的主要手段。近年来，这种治疗方式出现了一些有价值的改进。发现丙酸氯倍他索若作为强化脉冲疗法应用，能产生最高的即时反应，而且可能比其他化合物诱导更长时间的缓解。在优化的赋形剂中每日一次应用二丙酸倍他米松和糠酸莫米松至少与多次应用其他几种化合物的效果相同。有迹象表明糠酸莫米松的效力和副作用存在分离现象。因此，现在的皮质类固醇治疗比以前更能根据患者的需求进行调整。
