Sundram K, Hornstra G, von Houwelingen A C, Kester A D
Department of Human Biology, Limburg University, Maastricht, The Netherlands.
Br J Nutr. 1992 Nov;68(3):677-92. doi: 10.1079/bjn19920125.
Thirty-eight male volunteers participated in a double-blind cross-over trial evaluating the effect of replacing the usual sources of saturated fat in the Dutch diet (animal fats and hydrogenated oils) by palm oil, which is virtually free of cholesterol and trans-fatty acids, on serum lipids, lipoproteins and apolipoproteins. Maximum (about 70%) replacement had no significant effect on serum total cholesterol or most lipoprotein fractions, but resulted in an 11% increase in serum high-density-lipoprotein (HDL)2-cholesterol relative to the control (P2 = 0.01). The palm-oil diet also caused an 8% decrease in low-density-lipoprotein (LDL):HDL2 + HDL3-cholesterol ratio (P2 = 0.02) as well as a 9% decrease in triacylglycerols in the low-density-lipoprotein fractions (P2 = 0.01). Palm oil consumption resulted in a 4% increase in serum apolipoprotein AI (P2 = 0.008) and a 4% decrease in apolipoprotein B (P2 = 0.01) relative to the control diet; the B:AI apolipoprotein ratio was decreased by 8% (P2 < 0.0001). These results were not significantly affected by the different lipoprotein E phenotypes of the volunteers. Although the observed differences were relatively modest, the present study, nonetheless, indicates that dietary palm oil, when replacing a major part of the normal fat content in a Dutch diet, may slightly reduce the lipoprotein- and apolipoprotein-associated cardiovascular risk profiles.
38名男性志愿者参与了一项双盲交叉试验，该试验评估了用几乎不含胆固醇和反式脂肪酸的棕榈油替代荷兰饮食中常见饱和脂肪来源（动物脂肪和氢化油）对血清脂质、脂蛋白和载脂蛋白的影响。最大替代量（约70%）对血清总胆固醇或大多数脂蛋白组分没有显著影响，但相对于对照组，血清高密度脂蛋白（HDL）2胆固醇增加了11%（P2 = 0.01）。棕榈油饮食还使低密度脂蛋白（LDL）:HDL2 + HDL3胆固醇比值降低了8%（P2 = 0.02），低密度脂蛋白组分中的三酰甘油降低了9%（P2 = 0.01）。相对于对照饮食，食用棕榈油使血清载脂蛋白AI增加了4%（P2 = 0.008），载脂蛋白B降低了4%（P2 = 0.01）；载脂蛋白B:AI比值降低了8%（P2 < 0.0001）。志愿者不同的脂蛋白E表型对这些结果没有显著影响。尽管观察到的差异相对较小，但本研究表明，在荷兰饮食中，当用棕榈油替代大部分正常脂肪含量时，可能会略微降低与脂蛋白和载脂蛋白相关的心血管疾病风险。
