Malaysian Palm Oil Board, Persiaran Institusi, Bandar Baru Bangi, Kajang Selangor, Malaysia.
Br J Nutr. 2011 Dec;106(11):1655-63. doi: 10.1017/S0007114511002121. Epub 2011 Jun 6.
Waste from agricultural products represents a disposal liability, which needs to be addressed. Palm oil is the most widely traded edible oil globally, and its production generates 85 million tons of aqueous by-products annually. This aqueous stream is rich in phenolic antioxidants, which were investigated for their composition and potential in vitro biological activity. We have identified three isomers of caffeoylshikimic acid as major components of oil palm phenolics (OPP). The 2,2-diphenyl-1-picrylhydrazyl assay confirmed potent free radical scavenging activity. To test for possible cardioprotective effects of OPP, we carried out in vitro LDL oxidation studies as well as ex vivo aortic ring and mesenteric vascular bed relaxation measurements. We found that OPP inhibited the Cu-mediated oxidation of human LDL. OPP also promoted vascular relaxation in both isolated aortic rings and perfused mesenteric vascular beds pre-contracted with noradrenaline. To rule out developmental toxicity, we performed teratological studies on rats up to the third generation and did not find any congenital anomalies. Thus, these initial studies suggest that OPP is safe and may have a protective role against free radical damage, LDL oxidation and its attendant negative effects, as well as vascular constriction in mitigating atherosclerosis. Oil palm vegetation liquor thus represents a new source of phenolic bioactives.
农产品废弃物是一种需要处理的处置责任。棕榈油是全球交易量最大的食用油，其生产每年产生 8500 万吨水性副产物。这种水性料流富含酚类抗氧化剂，我们研究了其组成和潜在的体外生物活性。我们已经确定了咖啡酰莽草酸的三种异构体是油棕酚类化合物（OPP）的主要成分。2,2-二苯基-1-苦基肼试验证实了其具有很强的自由基清除活性。为了测试 OPP 是否具有可能的心脏保护作用，我们进行了体外 LDL 氧化研究以及离体主动脉环和肠系膜血管床松弛测量。我们发现 OPP 抑制了 Cu 介导的人 LDL 氧化。OPP 还促进了在去甲肾上腺素预收缩的离体主动脉环和灌注的肠系膜血管床中的血管松弛。为了排除发育毒性，我们对大鼠进行了三代的致畸学研究，没有发现任何先天畸形。因此，这些初步研究表明，OPP 是安全的，可能具有对抗自由基损伤、LDL 氧化及其伴随的负面作用以及血管收缩的保护作用，从而减轻动脉粥样硬化。因此，油棕植物液代表了酚类生物活性物质的一个新来源。
