Goa K L, Chrisp P
Adis International Limited, Auckland, New Zealand.
Drugs Aging. 1992 Nov-Dec;2(6):473-86. doi: 10.2165/00002512-199202060-00004.
Diclofenac sodium is a potent nonsteroidal anti-inflammatory drug with analgesic activity. When instilled as a topical 0.1% solution in a limited number of patients undergoing cataract surgery, diclofenac limits surgically induced miosis, reduces signs of ocular inflammation, does not cause elevations in intraocular pressure, and reduces the occurrence and severity of cystoid macular oedema. Preliminary findings suggest a niche for topical diclofenac in other ocular inflammatory conditions such as iritis, episcleritis and conjunctivitis, although its efficacy in these areas awaits confirmation. The drug appears well tolerated, apart from a transient burning sensation after instillation in some patients. Ocular diclofenac thus appears well suited as a local anti-inflammatory adjunct to cataract surgery, and may be useful in some other inflammatory ocular conditions.
双氯芬酸钠是一种具有镇痛活性的强效非甾体抗炎药。当以0.1%的局部溶液滴入少数接受白内障手术的患者眼中时，双氯芬酸钠可限制手术引起的瞳孔缩小，减轻眼部炎症迹象，不会导致眼压升高，并减少黄斑囊样水肿的发生和严重程度。初步研究结果表明，局部使用双氯芬酸钠在虹膜炎、巩膜炎和结膜炎等其他眼部炎症性疾病中具有一定作用，尽管其在这些领域的疗效尚待证实。除了一些患者滴入后有短暂的烧灼感外，该药物耐受性良好。因此，眼部用双氯芬酸钠似乎非常适合作为白内障手术的局部抗炎辅助药物，并且可能对其他一些眼部炎症性疾病有用。
