Tiley C, Grimwade D, Findlay M, Treleaven J, Height S, Catalano J, Powles R
Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
Leuk Lymphoma. 1992 Sep;8(1-2):143-6. doi: 10.3109/10428199209049828.
The acute tumour lysis syndrome is a well recognised complication of chemotherapy for lymphoid malignancies. There are few reports, however, of this complication after corticosteroid therapy alone. We report a case of T-cell acute lymphoblastic leukaemia who developed the biochemical picture of tumour lysis after two doses of hydrocortisone given prior to platelet transfusion. Prophylactic corticosteroids prior to blood product infusion should be reserved for patients who have experienced febrile or allergic reactions in the past and it is suggested that they should only be administered to patients with active lymphoid malignancies with due caution.
急性肿瘤溶解综合征是淋巴瘤化疗公认的并发症。然而，仅有少数关于单纯使用皮质类固醇治疗后出现该并发症的报道。我们报告1例T细胞急性淋巴细胞白血病患者，在输注血小板前给予两剂氢化可的松后出现了肿瘤溶解的生化表现。血液制品输注前的预防性皮质类固醇应仅用于既往有发热或过敏反应的患者，建议仅在谨慎的情况下给予患有活动性淋巴瘤的患者。
