Hynynen M, Olkkola K T, Palojoki R, Tikkanen I, Fyhrquist F
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Eur J Clin Pharmacol. 1992;43(6):647-50. doi: 10.1007/BF02284966.
The pharmacokinetics of a bolus dose of synthetic atrial natriuretic factor (ANF) 50 micrograms and its effects on urine output, blood pressure and plasma renin activity have been studied in 5 patients undergoing hypothermic cardiopulmonary bypass for cardiac surgery. The half-lives of the fast and slow components were 2.4 min and 14.2 min, respectively. The volume of the central compartment was 16.7 l and the volume of distribution at steady-state was 38.9 l. The total plasma clearance was 3.8 l.min-1. ANF significantly increased urine output and decreased blood pressure, but it did not affect plasma renin activity.
对5例接受心脏手术低温心肺转流的患者，研究了静脉注射50微克合成心钠素（ANF）的药代动力学及其对尿量、血压和血浆肾素活性的影响。快、慢成分的半衰期分别为2.4分钟和14.2分钟。中央室容积为16.7升，稳态分布容积为38.9升。总血浆清除率为3.8升·分钟⁻¹。心钠素显著增加尿量并降低血压，但不影响血浆肾素活性。
