健康受试者中α-人心房利钠多肽的药代动力学
The pharmacokinetics of alpha-human atrial natriuretic polypeptide in healthy subjects.
作者信息
Nakao K, Sugawara A, Morii N, Sakamoto M, Yamada T, Itoh H, Shiono S, Saito Y, Nishimura K, Ban T
出版信息
Eur J Clin Pharmacol. 1986;31(1):101-3. doi: 10.1007/BF00870995.
We have analysed the pharmacokinetics of alpha-human atrial natriuretic polypeptide (alpha-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7 +/- 0.07 min and 13.3 +/- 1.69 min respectively. V1 (the volume of the central compartment), VZ (volume of distribution) and VSS (volume of distribution at steady-state) were 5370 +/- 855 ml (89.5 +/- 14.3 ml X kg-1), 32000 +/- 4620 ml (533 +/- 77.0 ml X kg-1), and 11900 +/- 1530 ml (198 +/- 25.5 ml X kg-1) respectively. The mean plasma clearance was 1520 +/- 121 ml X min-1 (25.4 +/- 2.0 ml X min-1 X kg-1.
我们采用两室开放模型，在健康受试者静脉推注后分析了α-人心房利钠多肽（α-hANP）的药代动力学。快速和慢速成分的血浆半衰期分别为1.7±0.07分钟和13.3±1.69分钟。中央室容积（V1）、分布容积（VZ）和稳态分布容积（VSS）分别为5370±855毫升（89.5±14.3毫升×千克⁻¹）、32000±4620毫升（533±77.0毫升×千克⁻¹）和11900±1530毫升（198±25.5毫升×千克⁻¹）。平均血浆清除率为1520±121毫升×分钟⁻¹（25.4±2.0毫升×分钟⁻¹×千克⁻¹）。
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