Gillies A H, Crozier I G, Nicholls M G, Espiner E A, Yandle T G
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
J Clin Endocrinol Metab. 1987 Dec;65(6):1095-7. doi: 10.1210/jcem-65-6-1095.
The effect of posture on plasma atrial natriuretic peptide (ANP) levels during a constant iv infusion of the 28-amino acid polypeptide was investigated in 8 normal men. alpha-Human ANP was infused at a constant rate of 0.5 micrograms/min (162 pmol/min) while the men were supine, then erect, and finally when supine again. Plasma ANP levels rose from 10.9 +/- 1.6 (+/- SEM) to 33.3 +/- 2.4 pmol/L after 60 min of constant infusion with the men in the supine position. On standing, plasma ANP increased further to 40.6 +/- 3.4 pmol/L, then fell to 32.2 +/- 2.7 pmol/L with resumption of supine posture. The calculated MCR of ANP fell from a mean of 7.7 to 5.7 L/min on standing, but rose again to 7.6 L/min upon lying down. We conclude that body posture has a significant effect on the rate of clearance of ANP from plasma.
在8名正常男性中研究了姿势对持续静脉输注28氨基酸多肽期间血浆心房利钠肽（ANP）水平的影响。在男性仰卧时，然后直立时，最后再次仰卧时，以0.5微克/分钟（162皮摩尔/分钟）的恒定速率输注α-人ANP。在男性仰卧位持续输注60分钟后，血浆ANP水平从10.9±1.6（±SEM）上升至33.3±2.4皮摩尔/升。站立时，血浆ANP进一步增加至40.6±3.4皮摩尔/升，然后随着恢复仰卧姿势降至32.2±2.7皮摩尔/升。站立时计算出的ANP的MCR从平均7.7降至5.7升/分钟，但躺下后又升至7.6升/分钟。我们得出结论，身体姿势对血浆中ANP的清除率有显著影响。
