Machan Z A, Taylor G W, Pitt T L, Cole P J, Wilson R
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
J Antimicrob Chemother. 1992 Nov;30(5):615-23. doi: 10.1093/jac/30.5.615.
Clinical isolates of Pseudomonas aeruginosa produce low molecular weight, hydrophobic substances which inhibit the growth of Staphylococcus aureus and other Gram-positive organisms. The active substances have been purified from a culture of P. aeruginosa and characterized as a mixture of 2-heptyl-4-hydroxyquinoline N-oxide and its homologues. The alkyl-hydroxyquinolines (derived through reduction of the N-oxide) were also produced by P. aeruginosa cultures but, in general, were less active against S. aureus. 2-Heptyl-4-hydroxyquinoline was identified in a sample of human bronchial secretions from a patient with cystic fibrosis who was heavily colonized with P. aeruginosa. Production of antibacterial alkyl-hydroxyquinoline N-oxides in human lung may explain the observation that the presence of P. aeruginosa in the sputum of patients with cystic fibrosis is correlated with the absence of S. aureus.
铜绿假单胞菌的临床分离株会产生低分子量的疏水性物质，这些物质可抑制金黄色葡萄球菌和其他革兰氏阳性菌的生长。活性物质已从铜绿假单胞菌培养物中纯化出来，并鉴定为2-庚基-4-羟基喹啉N-氧化物及其同系物的混合物。铜绿假单胞菌培养物也会产生烷基-羟基喹啉（通过N-氧化物还原得到），但总体而言，其对金黄色葡萄球菌的活性较低。在一名严重感染铜绿假单胞菌的囊性纤维化患者的人支气管分泌物样本中鉴定出了2-庚基-4-羟基喹啉。人体肺部产生抗菌性烷基-羟基喹啉N-氧化物可能解释了以下观察结果：囊性纤维化患者痰液中存在铜绿假单胞菌与不存在金黄色葡萄球菌相关。
