Ueno Y
Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Prikl Biokhim Mikrobiol. 1992 Nov-Dec;28(6):899-906.
Toxicological investigations of "Yellow Rice" which have been contaminated with various Penicillium species have shown that Penicillium islandicum apart from well-known hepatotoxic mycotoxin, lyteoskyrin synthesizes cyclochlorotine (chloropeptide, CP), which is also hepatotoxic. Isolation of chloropeptide and its chemical characteristics, acute toxicity and biochemical alterations, tissue distribution and excretion, deformation of hepatic cells, and interaction with cytoskeleton filaments are described. It is shown that the hepatotoxicity of CP is inactivated by dehalogenation of CP by the cytochrome P-450 system.
对被多种青霉菌污染的“黄变米”进行的毒理学研究表明，除了著名的肝毒性霉菌毒素岛青霉素外，岛青霉还能合成环氯素（氯肽，CP），其也具有肝毒性。文中描述了氯肽的分离及其化学特性、急性毒性和生化改变、组织分布与排泄、肝细胞变形以及与细胞骨架丝的相互作用。结果表明，细胞色素P - 450系统对CP进行脱卤作用可使CP的肝毒性失活。
