冰岛青霉（Penicillium islandicum Sopp）产生的肝毒性含氯肽
Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.
作者信息
Ishii K, Ueno Y
出版信息
Appl Microbiol. 1973 Sep;26(3):359-63. doi: 10.1128/am.26.3.359-363.1973.
Abstract
Twenty-six strains of Penicillium islandicum Sopp were tested for production of a chlorine-containing peptide (Cl-peptide), which is a hepatotoxin. Highest levels of the mycotoxin were produced in a modification of Wickerham medium. The mycotoxin was isolated by adsorption on charcoal and, after washing the charcoal with acetone-water (1:1), was eluted into n-butanol. Further purification was accomplished by gel filtration. Maximum yields were 10 to 20 mg of toxin per liter of culture filtrate.
摘要
对26株冰岛青霉进行了测试，以检测其含氯肽（Cl-肽）的产生情况，该含氯肽是一种肝毒素。在改良的威克汉姆培养基中，该霉菌毒素的产量最高。通过吸附在木炭上分离出霉菌毒素，用丙酮-水（1:1）洗涤木炭后，将其洗脱到正丁醇中。通过凝胶过滤进一步纯化。每升培养滤液的最大产量为10至20毫克毒素。
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引用本文的文献
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A convenient thin layer chromatographic method for the detection of cyclochlorotine and simatoxin, toxins from Penicillium islandicum Sopp.一种用于检测环氯素和岛青霉素毒素（来自冰岛青霉的毒素）的简便薄层色谱法。
Experientia. 1978 Jun 15;34(6):819-20. doi: 10.1007/BF01947348.
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本文引用的文献
1
Chemical determination of the chlorine-containing peptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp.
J Biochem. 1970 Jun;67(6):753-8. doi: 10.1093/oxfordjournals.jbchem.a129306.
2
Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.冰岛青霉（Penicillium islandicum Sopp）产生肝毒性色素黄绿青霉素。
Appl Microbiol. 1969 Sep;18(3):406-9. doi: 10.1128/am.18.3.406-409.1969.
3
Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochlorotine.
Food Cosmet Toxicol. 1972 Apr;10(2):193-207. doi: 10.1016/s0015-6264(72)80197-4.
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