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Chemical determination of the chlorine-containing peptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp.
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The bioassay of aflatoxins and related substances with Bacillus megaterium spores and chick embryos.用巨大芽孢杆菌孢子和鸡胚对黄曲霉毒素及相关物质进行生物测定。
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Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.冰岛青霉（Penicillium islandicum Sopp）产生的肝毒性含氯肽
Appl Microbiol. 1973 Sep;26(3):359-63. doi: 10.1128/am.26.3.359-363.1973.
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7
Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochlorotine.
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Mycotoxins.
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9
Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.从冰岛青霉中生产橙黄红菌素并分离出一种新的代谢产物，皮巴斯托醇。
Appl Environ Microbiol. 1978 Mar;35(3):563-6. doi: 10.1128/aem.35.3.563-566.1978.

岛青霉产生环氯素和一种新的代谢产物——岛青霉素。

Production of cyclochlorotine and a new metabolite, simatoxin, by Penicillium islandicum Sopp.

作者信息

Ghosh A C, Manmade A, Townsend J M, Bousquet A, Howes J F, Demain A L

出版信息

Appl Environ Microbiol. 1978 Jun;35(6):1074-8. doi: 10.1128/aem.35.6.1074-1078.1978.

DOI:10.1128/aem.35.6.1074-1078.1978
PMID:677874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC242987/
Abstract

Production of the hepatotoxin cyclochlorotine by Penicillium islandicum was studied under a variety of fermentation conditions. The best system for production was agitated red wheat. A thin-layer chromatographic method was developed for the detection of this cyclic polypeptide. These experiments have resulted in the isolation of a new toxic metabolite, which we call simatoxin.

摘要

在多种发酵条件下研究了岛青霉产生肝毒素环氯素的情况。最佳生产体系是搅拌的红小麦。开发了一种薄层色谱法用于检测这种环肽。这些实验已分离出一种新的有毒代谢产物，我们称之为西马毒素。