岛青霉产生环氯素和一种新的代谢产物——岛青霉素。
Production of cyclochlorotine and a new metabolite, simatoxin, by Penicillium islandicum Sopp.
作者信息
Ghosh A C, Manmade A, Townsend J M, Bousquet A, Howes J F, Demain A L
出版信息
Appl Environ Microbiol. 1978 Jun;35(6):1074-8. doi: 10.1128/aem.35.6.1074-1078.1978.
Abstract
Production of the hepatotoxin cyclochlorotine by Penicillium islandicum was studied under a variety of fermentation conditions. The best system for production was agitated red wheat. A thin-layer chromatographic method was developed for the detection of this cyclic polypeptide. These experiments have resulted in the isolation of a new toxic metabolite, which we call simatoxin.
摘要
在多种发酵条件下研究了岛青霉产生肝毒素环氯素的情况。最佳生产体系是搅拌的红小麦。开发了一种薄层色谱法用于检测这种环肽。这些实验已分离出一种新的有毒代谢产物，我们称之为西马毒素。
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本文引用的文献
1
Study of the toxic principle in yellow rice.
Pharm Bull. 1955 Dec;3(6):476-7. doi: 10.1248/cpb1953.3.476.
2
Chemical determination of the chlorine-containing peptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp.
J Biochem. 1970 Jun;67(6):753-8. doi: 10.1093/oxfordjournals.jbchem.a129306.
3
Biotechnology report. Solid state fermentations.
Biotechnol Bioeng. 1972 Jul;14(4):517-32. doi: 10.1002/bit.260140402.
4
The bioassay of aflatoxins and related substances with Bacillus megaterium spores and chick embryos.
J Am Oil Chem Soc. 1968 Oct;45(10):700-2. doi: 10.1007/BF02541261.
5
Production of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.
Appl Microbiol. 1973 Sep;26(3):359-63. doi: 10.1128/am.26.3.359-363.1973.
6
Some recent studies on the metabolites of fungi and lichens.
Pure Appl Chem. 1973;33(1):109-28. doi: 10.1351/pac197333010109.
7
Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochlorotine.
Food Cosmet Toxicol. 1972 Apr;10(2):193-207. doi: 10.1016/s0015-6264(72)80197-4.
8
Mycotoxins.
Annu Rev Pharmacol. 1975;15:437-51. doi: 10.1146/annurev.pa.15.040175.002253.
9
Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.
Appl Environ Microbiol. 1978 Mar;35(3):563-6. doi: 10.1128/aem.35.3.563-566.1978.
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