Terao K, Ito E, Tatsuno T
Arch Toxicol. 1984 Mar;55(1):39-46. doi: 10.1007/BF00316584.
Sequential morphological changes in murine liver induced by cyclochlorotine (CC), a secondary metabolite of Penicillium islandicum were investigated by transmission electron microscopy and scanning electron microscopy. Within 15 min after the administration of CC there was a marked dilatation of Disse's space around the portal triads, and the exudates then poured out into the space which was formed by the invagination of the hepatocyte plasma membrane. Shortly after the invagination was completed, the connection between Disse's space and the invaginated space was pinched off, so that this space became a membrane-bound vacuole. After dehydration, the vacuoles became granular. The liver injuries induced by CC were influenced by various pretreatments. The results indicate that drug-metabolizing systems mediated by cytochrome p-450 in the hepatocytes may play an important role in the hepatotoxicity of CC.
通过透射电子显微镜和扫描电子显微镜研究了由冰岛青霉的次生代谢产物环氯素（CC）诱导的小鼠肝脏的连续形态变化。给予CC后15分钟内，门三联周围的狄氏间隙明显扩张，渗出物随后倒入由肝细胞质膜内陷形成的间隙中。内陷完成后不久，狄氏间隙与内陷间隙之间的连接被掐断，使得这个间隙变成一个膜结合的液泡。脱水后，液泡变成颗粒状。CC诱导的肝损伤受各种预处理的影响。结果表明，肝细胞中由细胞色素p-450介导的药物代谢系统可能在CC的肝毒性中起重要作用。
