血清对蛋白水解酶抑制作用的研究。II. 血清中存在不同蛋白水解抑制剂的证明；它们的独特性质及其作用的特异性。
Studies on the inhibition of proteolytic enzymes by serum. II. Demonstration that separate proteolytic inhibitors exist in serum; their distinctive properties and the specificity of their action.
作者信息
SHULMAN N R
出版信息
J Exp Med. 1952 Jun;95(6):593-603. doi: 10.1084/jem.95.6.593.
Abstract
Increases in serum proteolytic inhibition with disease were found to be specific either for plasmin or for trypsin and chymotrypsin. In normal serum, the plasmin inhibitor could be differentiated from the trypsin and chymotrypsin inhibitor by various physical and chemical means. There was no apparent difference between the trypsin inhibitor and the chymotrypsin inhibitor in serum. No qualitative differences were found between the inhibitors of normal sera and the inhibitors of sera showing elevated inhibition.
摘要
研究发现，随着疾病发展，血清中蛋白水解抑制作用的增强对纤溶酶或胰蛋白酶及糜蛋白酶具有特异性。在正常血清中，纤溶酶抑制剂可通过多种物理和化学方法与胰蛋白酶及糜蛋白酶抑制剂区分开来。血清中的胰蛋白酶抑制剂和糜蛋白酶抑制剂之间没有明显差异。正常血清抑制剂与抑制作用增强的血清抑制剂之间未发现定性差异。
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