Widimský J, Cihák R, Fedelesová V, Lefflerová K, Mayer O, Uhlír O
Subkatedra kardiologie ILF Praha.
Vnitr Lek. 1992 Nov;38(11):1066-71.
A multicentre investigation of antihypertensive treatment by perindopril was conducted in three centres of Czechoslovakia. The investigation comprised 51 patients with mild to moderate essential hypertension (diastolic pressure 95-115 mmHg) who were taking perindopril for a period of three months, the initial dose being 4 mg (1 tablet per day). If the blood pressure did not drop to normal levels (dBP < 90 mmHg), the dose was increased to 8 mg after 1 month and if after 2 months of treatment the blood pressure did not reach normal levels, a thiazide diuretic was added. The antihypertensive effectiveness was assessed 24 hours after ingestion of the drug. The blood pressure declined significantly already after the first month of monotherapy with perindopril. It declined then significantly up to the end of the 3rd month of treatment. The systolic blood pressure declined by 9.4 mmHg after the first month of monotherapy with perindopril and by 15.9 mmHg after 3 months of treatment. The diastolic blood pressure declined by 8.1 mmHg after one month of monotherapy and by 12.4 mmHg at the end of three-month treatment. The clinical and biological tolerance was excellent and only one patient discontinued treatment for reasons not related to the administered drug. Twenty-four hour monitoring of the blood pressure also proved the favourable effect of perindopril.
在捷克斯洛伐克的三个中心开展了一项关于培哚普利降压治疗的多中心研究。该研究纳入了51例轻度至中度原发性高血压患者（舒张压95 - 115 mmHg），他们服用培哚普利三个月，初始剂量为4 mg（每日1片）。如果血压未降至正常水平（舒张压<90 mmHg），1个月后剂量增加至8 mg，若治疗2个月后血压仍未达到正常水平，则加用噻嗪类利尿剂。在服药24小时后评估降压效果。单用培哚普利治疗的第一个月后血压就显著下降，然后在治疗的第3个月末仍显著下降。单用培哚普利治疗1个月后收缩压下降9.4 mmHg，治疗3个月后下降15.9 mmHg。单用培哚普利1个月后舒张压下降8.1 mmHg，3个月末下降12.4 mmHg。临床和生物学耐受性良好，只有1例患者因与所服药物无关的原因停药。24小时血压监测也证实了培哚普利的良好效果。
