疱疹病毒与宿主细胞线粒体的关系。
The relation of herpes virus to host cell mitochondria.
作者信息
ACKERMANN W W, KURTZ H
出版信息
J Exp Med. 1952 Aug;96(2):151-7. doi: 10.1084/jem.96.2.151.
Abstract
The intracellular distribution of herpes virus in embryonic liver was investigated. 80 per cent of the virus was found in the cytoplasm in what appears to be a form uncombined with mitochondria or nuclei. A significant amount of the virus (16 per cent) was found bound to the mitochondria by an intimate attachment. Furthermore evidence was obtained that the mitochondria from liver tissue undergo a selective deterioration when infected with herpes virus. The concept is advanced that these organelles function in the development of virus.
摘要
对疱疹病毒在胚胎肝脏中的细胞内分布进行了研究。发现80%的病毒存在于细胞质中，其形态似乎未与线粒体或细胞核结合。发现大量病毒（16%）通过紧密附着与线粒体结合。此外，有证据表明，感染疱疹病毒时，肝脏组织中的线粒体发生选择性退化。有人提出这样一种观点，即这些细胞器在病毒的发育过程中发挥作用。
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