Chabriat H
Service Hospitalier Frédéric Joliot, Orsay, France.
Pathol Biol (Paris). 1992 Apr;40(4):344-8.
Positron emission tomography (PET) is a brain imaging technique that allows in vivo studies of numerous physiological parameters. There have been few PET studies in migraine patients. Cerebral blood flow changes with no variations in brain oxygen consumption have been reported in patients with prolonged neurologic manifestations during migraine attacks. Parenteral administration of reserpine during migraine headache has been followed by a fall in the overall cerebral uptake of glucose. The small sample sizes and a number of methodologic problems complicate the interpretation of these results. Recent technical advances and the development of new PET tracers can be expected to provide further insight into the pathophysiology of migraine. Today cerebral cortex 5 HT2 serotonin receptors can be studied in migraine patients with PET.
正电子发射断层扫描（PET）是一种脑成像技术，可用于对多种生理参数进行活体研究。偏头痛患者的PET研究较少。据报道，偏头痛发作期间出现长期神经症状的患者脑血流量发生变化，但脑氧消耗无变化。偏头痛头痛发作时静脉注射利血平后，大脑对葡萄糖的总体摄取量会下降。样本量小以及一些方法学问题使这些结果的解读变得复杂。预计近期的技术进步和新型PET示踪剂的开发将为深入了解偏头痛的病理生理学提供更多线索。如今，可以用PET对偏头痛患者的大脑皮层5-HT2血清素受体进行研究。
