Sadzot B, Maquet P, Franck G
Department of Neurology, University of Liège, Belgium.
Cephalalgia. 1995;15(4):316-22. doi: 10.1046/j.1468-2982.1995.1504316.x.
Despite the high prevalence of migraine in the population, the pathophysiology of this condition remains poorly understood. Vascular changes have been postulated. With positron emission tomography and various radiotracers, it is possible to have a non-invasive access to a number of parameters of interest in migraine research. These are presented and discussed in this article. PET has great potential for answering some basic questions concerning the physiological or biochemical changes that can occur during and between migraine attacks. Few studies have been published, however, probably because of (i) limitations inherent to the technique and (ii) problems in study design.
尽管偏头痛在人群中的患病率很高，但这种疾病的病理生理学仍未得到充分了解。有人提出了血管变化的假说。借助正电子发射断层扫描和各种放射性示踪剂，可以对偏头痛研究中一些感兴趣的参数进行非侵入性检测。本文将介绍并讨论这些参数。正电子发射断层扫描在回答一些有关偏头痛发作期间及发作间期可能发生的生理或生化变化的基本问题方面具有巨大潜力。然而，可能由于（i）该技术固有的局限性和（ii）研究设计中的问题，相关研究发表得很少。
