Welch K M, Levine S R, D'Andrea G, Schultz L R, Helpern J A
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Neurology. 1989 Apr;39(4):538-41. doi: 10.1212/wnl.39.4.538.
We measured brain energy phosphate metabolism and intracellular pH (pHi) in a cross-sectional study of migraine patients by in vivo phosphorus 31 NMR spectroscopy. During a migraine attack the ratio ATP/total phosphate signal (mole % ATP) was preserved, but there was a decrease in mole % phosphocreatine (PCr) and an increase in mole % inorganic phosphate (Pi) resulting in a decrease of the PCr/Pi ratio, an index of brain phosphorylation potential. This was found in classic but not common migraine. Mole % Pi was also increased in combined brain regions between attacks. There was no alteration in brain pHi during or between attacks. Energy phosphate metabolism but not pHi appears disordered during a migraine attack.
在一项针对偏头痛患者的横断面研究中，我们通过体内磷-31核磁共振波谱法测量了脑能量磷酸盐代谢和细胞内pH值（pHi）。在偏头痛发作期间，ATP/总磷酸盐信号比值（摩尔百分比ATP）保持不变，但磷酸肌酸（PCr）的摩尔百分比降低，无机磷酸盐（Pi）的摩尔百分比增加，导致PCr/Pi比值降低，这是脑磷酸化潜能的一个指标。这一现象在典型偏头痛而非普通偏头痛中被发现。在发作间期，联合脑区的Pi摩尔百分比也升高。发作期间及发作间期脑pHi均无变化。在偏头痛发作期间，能量磷酸盐代谢似乎紊乱，但pHi没有改变。
