Robertson C F, Rubinfeld A R, Bowes G
Thoracic Medicine Department, Royal Children's Hospital, Parkville, Victoria, Australia.
Pediatr Pulmonol. 1992 Jun;13(2):95-100. doi: 10.1002/ppul.1950130207.
Previous reviews of pediatric asthma mortality have mostly been from hospital-based clinic populations and suggest that only those with severe asthma are most at risk. This report summarizes an investigation, by interviewer-administered questionnaire, into the circumstances surrounding the death in all patients aged 20 years or less who died from asthma in the State of Victoria over a 3 year period from May 1, 1986. During this period, 51 deaths due to asthma were reported. Thirty-three percent of these were judged to have a history of trivial or mild asthma, and 32% had no previous hospital admission for asthma. However, 36% were judged to have had severe asthma, 43% were taking regular inhaled beclomethasone or sodium cromoglycate, and 10% were taking regular oral steroids. Twenty-two percent had a previous admission to an ICU. Death occurred outside hospital in 40 (78%) subjects. In the final attack 63% had sudden onset and collapse within minutes, 12% were found dead, and 25% had acute progression of an established attack. The investigators assessed 39% of the deaths to have had potentially preventable elements. The preventable factors included: inadequate assessment or therapy of prior asthma (68%), poor compliance with therapy (53%), and delay in seeking help (47%). The majority of subjects in this survey could not be classified as "high risk." Therefore, clinicians should ensure that all young patients with asthma are aware of optimal maintenance management, can recognize deteriorating asthma, and follow a clear individualized crisis plan.
以往对儿童哮喘死亡率的综述大多来自以医院为基础的门诊人群,表明只有重度哮喘患者风险最高。本报告总结了一项调查,通过访谈者发放问卷,调查了1986年5月1日起三年间维多利亚州所有20岁及以下死于哮喘的患者的死亡相关情况。在此期间,共报告了51例哮喘死亡病例。其中33%被判定有轻微或轻度哮喘病史,32%此前未曾因哮喘住院。然而,36%被判定患有重度哮喘,43%正在规律吸入倍氯米松或色甘酸钠,10%正在规律口服类固醇。22%曾入住重症监护病房。40例(78%)患者死于院外。在最后一次发作中,63%在数分钟内突然发病并虚脱,12%被发现死亡,25%已有发作急性进展。调查人员评估39%的死亡病例存在潜在可预防因素。可预防因素包括:先前哮喘评估或治疗不足(68%)、治疗依从性差(53%)以及寻求帮助延迟(47%)。本次调查中的大多数患者不能归类为“高危”。因此,临床医生应确保所有哮喘患儿了解最佳维持治疗管理方法,能够识别哮喘恶化情况,并遵循明确的个体化危机处理计划。