Johnson A J, Nunn A J, Somner A R, Stableforth D E, Stewart C J
Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1870-2. doi: 10.1136/bmj.288.6434.1870.
Mortality from asthma in England and Wales has remained unchanged for at least 20 years, even in the age group 15-44. Yet in those 20 years "modern" drugs have been introduced for the treatment of asthma, such as beta 2 agonist bronchodilators and corticosteroids. Why do patients still die? Detailed review of the circumstances of 90 deaths from asthma showed that a few were inevitable but that in the remainder four main sets of circumstances in the fatal attack contributed to the death. These were, firstly, the patient's failure to recognise the severity of the asthma; secondly, very rapid progress in the severity of the attack; thirdly, misjudgment in the management of the attack; and, fourthly, delay from many causes. Patients admitted to hospital with severe acute asthma usually survive. Those at risk of a life threatening attack should be identified and taught to monitor the severity and progress of their asthma objectively. Their direct admission to hospital should be facilitated.
在英格兰和威尔士,至少20年来哮喘死亡率一直保持不变,即使在15至44岁年龄组也是如此。然而在这20年里,已经引入了“现代”药物来治疗哮喘,如β2激动剂支气管扩张剂和皮质类固醇。为什么患者仍然死亡?对90例哮喘死亡病例的详细情况审查表明,少数死亡不可避免,但在其余病例中,致命发作的四种主要情况导致了死亡。首先,患者未能认识到哮喘的严重程度;其次,发作严重程度进展非常迅速;第三,对发作处理的判断失误;第四,多种原因导致的延误。因严重急性哮喘入院的患者通常能够存活。应识别出有危及生命发作风险的患者,并教导他们客观监测哮喘的严重程度和进展情况。应便利他们直接入院。