Linnenberg H S, Medici T C, Rhyner K
Departement für Innere Medizin, Universität Zürich.
Pneumologie. 1992 Jun;46(6):229-35.
Sarcoidosis and malignant lymphoma can occur in the same patient; sarcoidosis appears first, the malignant lymphoma follows later. The case histories of three patients illustrate what Brinker first coined as the "sarcoidosis-lymphoma syndrome". In two patients a pulmonary sarcoidosis stage I was diagnosed over 30 years respectively 4 years prior to the histological diagnosis of highly malignant Non-Hodgkin lymphoma. The third patient suffered from generalized sarcoidosis with splenomegaly, , granulomatous hepatitis and interstitial lung disease, in addition to which a lymphoproliferative syndrome was diagnosed. Comparing the pathogenesis of malignant lymphoma and sarcoidosis, parallels such as T-cell dysfunction, which probably facilitates malignant transformation of B-cells, become apparent. In both diseases the transforming gene could be the Ebstein-Barr virus.
结节病和恶性淋巴瘤可发生于同一患者；结节病先出现，恶性淋巴瘤随后发生。三位患者的病例史说明了布林克最初所称的“结节病-淋巴瘤综合征”。在两名患者中，分别在组织学诊断为高度恶性非霍奇金淋巴瘤的30多年和4年前诊断出I期肺结节病。第三位患者患有全身性结节病，伴有脾肿大、肉芽肿性肝炎和间质性肺病，此外还诊断出淋巴增殖综合征。比较恶性淋巴瘤和结节病的发病机制，T细胞功能障碍等相似之处变得明显，这可能促进B细胞的恶性转化。在这两种疾病中，转化基因可能都是爱泼斯坦-巴尔病毒。
