Rutgers J L, Bell D A
Department of Pathology, University of California, Los Angeles.
Mod Pathol. 1992 Jul;5(4):367-71.
A panel of monoclonal antibodies (MAbs) including MOv2, MOv8, anti-CA 19-9, and anti-carcinoembryonic antigen (CEA), and a polyclonal antibody against CEA, was applied to three types of ovarian borderline tumors. The tumors included 19 intestinal-type mucinous borderline tumors (IMBTs), 22 endocervical-like mucinous borderline tumors (EMBTs), and 23 mixed-epithelial borderline tumors (MEBTs); the latter two tumors are of mullerian type. Statistically significant differences in the percentage of positive IMBTs compared to the mullerian tumors were seen for anti-CEA and MOv8; strikingly different staining patterns were also seen. IMBTs were more often and more diffusely CEA-positive than were the mullerian tumors; within the mullerian tumors, only one type of cell, the indifferent eosinophilic cell, was consistently CEA positive. The MAbs MOv2, MOv8, and anti-CA 19-9 showed more extensive positivity in the mullerian tumors than in the IMBTs. This study highlights the differences in cell types between IMBTs and these two types of mullerian borderline tumors.
一组单克隆抗体（MAbs），包括MOv2、MOv8、抗CA 19-9和抗癌胚抗原（CEA），以及一种抗CEA多克隆抗体，被应用于三种类型的卵巢交界性肿瘤。这些肿瘤包括19例肠型黏液性交界性肿瘤（IMBTs）、22例宫颈内膜样黏液性交界性肿瘤（EMBTs）和23例混合上皮交界性肿瘤（MEBTs）；后两种肿瘤为苗勒氏型。抗CEA和MOv8显示，IMBTs阳性百分比与苗勒氏肿瘤相比有统计学显著差异；还观察到明显不同的染色模式。IMBTs比苗勒氏肿瘤更常且更弥漫地呈CEA阳性；在苗勒氏肿瘤中，只有一种细胞，即无特异性嗜酸性细胞，始终呈CEA阳性。MAbs MOv2、MOv8和抗CA 19-9在苗勒氏肿瘤中显示出比IMBTs更广泛的阳性。这项研究突出了IMBTs与这两种苗勒氏交界性肿瘤之间细胞类型的差异。
