Vorob'ev V E
Aviakosm Ekolog Med. 2003;37(6):41-5.
Invasive and non-invasive measurements were used to evaluate methods of correcting oxygen consumption and extraction within the local circulation in bedrested human subjects. For the first time demonstrated was the vanity of attempts to improve O2 supply to the human peripheral tissues by re-establishment of the circulating blood volume and increasing oxygen content in the affluent blood. The reason can be that HD bed rest impacts the ability of peripheral tissues to augment consumption of the surplus oxygen. The experiment showed that preliminary infusion of an antihypoxant (gamma-hydroxibutyric acid) recovers this ability even in case of abundant oxygen. Based on results of the investigation, oxygen supply correction can be considered as a way to improve (when necessary) oxygen supply to the human peripheral tissues during HD bed rest.
采用侵入性和非侵入性测量方法来评估卧床人体受试者局部循环中校正氧消耗和氧摄取的方法。首次证明，试图通过恢复循环血量和增加富氧血液中的氧含量来改善人体外周组织的氧供应是徒劳的。原因可能是卧床休息会影响外周组织增加对多余氧气消耗的能力。实验表明，即使在氧气充足的情况下，预先输注抗低氧剂（γ-羟基丁酸）也能恢复这种能力。根据研究结果，氧供应校正可被视为一种在卧床休息期间（必要时）改善人体外周组织氧供应的方法。
