Sapegin I D, Beketov A I
Eksp Klin Farmakol. 1993 Jan-Feb;56(1):28-31.
The effects of Picamilonum, 10 mg/kg, and Phenibutum, 50 mg/kg, on the cerebral blood flow, oxygen saturation and vascular reactivity in the cerebral cortex, thalamus, and hypothalamus were studied at rest during antiorthostatic hypokinesia and while rocking in antiorthostasis. Picamilonum was shown to have more steady vasodilatory effect, but it decreased a cerebrovascular response to CO2 and O2 inhalation. The reactivity of cerebral vessels to antiorthostasis under the influence of the drugs inversed, that of cerebrovascular vessels to CO2 inhalation decreased. Picamilonum enhanced vasoconstrictory responses to CO2 inhalation, whereas Phenibutum decreased it. With the combined effects of Phenibutum and Picamilonum, while rocking in antiorthostasis, a phase of vasodilatation was not observed and oxygen saturation and cerebrovascular reactivity were decreased.
研究了10毫克/千克匹卡米隆和50毫克/千克苯乙哌啶酮对静息状态下、抗立位耐力降低期间以及抗立位摇摆期间大脑皮层、丘脑和下丘脑的脑血流量、血氧饱和度和血管反应性的影响。结果显示，匹卡米隆具有更稳定的血管舒张作用，但它降低了脑血管对吸入二氧化碳和氧气的反应。在药物影响下，脑血管对抗立位的反应性发生逆转，对吸入二氧化碳的反应性降低。匹卡米隆增强了对吸入二氧化碳的血管收缩反应，而苯乙哌啶酮则降低了这种反应。在抗立位摇摆期间，苯乙哌啶酮和匹卡米隆联合作用时，未观察到血管舒张阶段，血氧饱和度和脑血管反应性降低。
