Tang Alice M
Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts, USA.
AIDS Read. 2003 Dec;13(12 Suppl):S23-7.
Wasting syndrome has been a common HIV-related condition reported in the United States. Three analyses from the Tufts Nutrition for Healthy Living study shed new light on the syndrome. Analysis of Cox proportional hazards models showed that losses in weight, fat-free mass, body cell mass, and fat mass, both from baseline weight and from weight at previous follow-up, were all significant indicators of mortality in patients with the HIV wasting syndrome. In the second analysis, the prevalence of 5% weight loss from the previous visit was shown to be 35% greater in the late HAART era, from 1998 to 2003, than in the early HAART era of 1995 to 1997 (P < .02). This corresponds with earlier observations that the diagnosis of HIV wasting had been increasing during the decade of the 1990s. In the third analysis, the researchers found that body weight, fat-free mass, and body mass index improved in patients receiving nutritional intervention compared with patients receiving placebo.
消瘦综合征一直是美国报告的一种常见的与艾滋病病毒相关的病症。塔夫茨健康生活营养研究的三项分析为该综合征提供了新的线索。对Cox比例风险模型的分析表明，无论是相对于基线体重还是相对于上一次随访时的体重，体重、去脂体重、体细胞质量和脂肪量的减少都是艾滋病病毒消瘦综合征患者死亡率的显著指标。在第二项分析中，结果显示，在1998年至2003年的高效抗逆转录病毒治疗（HAART）晚期，相比1995年至1997年的HAART早期，体重较上次就诊时减轻5%的患病率高出35%（P < 0.02）。这与早期观察结果一致，即在20世纪90年代的十年间，艾滋病病毒消瘦症的诊断一直在增加。在第三项分析中，研究人员发现，与接受安慰剂的患者相比，接受营养干预的患者的体重、去脂体重和体重指数有所改善。
