Alexander E
Division of Molecular and Clinical Rheumatology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Rheum Dis Clin North Am. 1992 Aug;18(3):637-72.
Although peripheral nervous system disease is a well-established complication of primary Sjögren's syndrome (SS), until relatively recently little attention has been focused on the central nervous system (CNS) complications of this disorder. The observations discussed in this article pertain to patients with primary SS in whom the presence of a second connective tissue disorder and other etiologies for neurologic disease have been rigorously excluded. In this article, the growing clinical spectrum of CNS manifestations, neurodiagnostic techniques, serologic analyses, and immunogenetic markers associated with this disorder are reviewed.
尽管周围神经系统疾病是原发性干燥综合征（SS）公认的并发症，但直到最近，人们才开始关注这种疾病的中枢神经系统（CNS）并发症。本文所讨论的观察结果涉及原发性SS患者，在这些患者中，已严格排除了第二种结缔组织疾病的存在以及神经系统疾病的其他病因。本文将对与该疾病相关的CNS表现不断扩大的临床范围、神经诊断技术、血清学分析和免疫遗传标记进行综述。
