男性的镁摄入量与冠心病风险

Magnesium intake and risk of coronary heart disease among men.

作者信息

Al-Delaimy Wael K, Rimm Eric B, Willett Walter C, Stampfer Meir J, Hu Frank B

机构信息

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

出版信息

J Am Coll Nutr. 2004 Feb;23(1):63-70. doi: 10.1080/07315724.2004.10719344.

DOI:10.1080/07315724.2004.10719344

PMID:14963055

Abstract

OBJECTIVE

Our aim in this study was to assess the relationship between magnesium intake and risk of coronary heart disease (CHD) among men.

METHODS

A total of 39,633 men in the Health Professionals Follow-up Study who returned a dietary questionnaire in 1986 were followed up for 12 years. Intakes of magnesium, zinc and potassium and other nutrients were assessed in 1986, 1990 and 1994. Total CHD incidence (nonfatal myocardial infarction (MI) and fatal CHD) was ascertained by biennial questionnaire and mortality surveillance confirmed by medical record review. Standard CHD risk factors were recorded biennially.

RESULTS

During 12 years of follow-up (414,285 person-years), we documented 1,449 cases of total CHD (1,021 non-fatal MI cases, and 428 fatal CHD). The age-adjusted relative risk (RR) of developing CHD in the highest quintile (median intake = 457 mg/day) compared with the lowest quintile (median intake = 269 mg/day) was 0.73 (95% CI 0.62-0.87, p for trend <0.0001). After controlling for standard CHD risk factors and dietary factors, the RR for developing CHD among men in the highest total magnesium intake quintile compared with those in the lowest was 0.82 (95% CI 0.65-1.05, p for trend = 0.08). For supplemental magnesium intake, the RR comparing the highest quintile to non-supplement users was 0.77 (95% CI 0.56-1.06, p for trend = 0.14).

CONCLUSIONS

These results suggest that intake of magnesium may have a modest inverse association with risk of CHD among men.

摘要

目的

本研究旨在评估男性镁摄入量与冠心病（CHD）风险之间的关系。

方法

健康专业人员随访研究中共有39633名男性在1986年返回了饮食问卷，并进行了12年的随访。在1986年、1990年和1994年评估了镁、锌、钾和其他营养素的摄入量。通过两年一次的问卷调查确定总的冠心病发病率（非致命性心肌梗死（MI）和致命性冠心病），并通过病历审查确认死亡率监测情况。每两年记录一次标准的冠心病风险因素。

结果

在12年的随访期间（414285人年），我们记录了1449例总的冠心病病例（1021例非致命性MI病例和428例致命性冠心病）。与最低五分位数（中位数摄入量 = 269毫克/天）相比，最高五分位数（中位数摄入量 = 457毫克/天）患冠心病的年龄调整相对风险（RR）为0.73（95%可信区间0.62 - 0.87，趋势p值<0.0001）。在控制了标准的冠心病风险因素和饮食因素后，总镁摄入量最高五分位数的男性与最低五分位数的男性相比，患冠心病的RR为0.82（95%可信区间0.65 - 1.05，趋势p值 = 0.08）。对于补充镁摄入量，最高五分位数与非补充使用者相比的RR为0.77（95%可信区间0.56 - 1.06，趋势p值 = 0.14）。