Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Department of Public Health, Ehime University Graduate School of Medicine, Toon, Japan.
Clin Nutr. 2018 Oct;37(5):1602-1608. doi: 10.1016/j.clnu.2017.08.006. Epub 2017 Aug 12.
BACKGROUND & AIMS: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population.
SUBJECTS/METHODS: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire.
After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes.
Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.
膳食镁摄入量与中风和冠心病（CHD）发病率之间的关联在亚洲人群中并不一致，也尚未确定。本研究旨在确定日本人群中膳食镁摄入量与中风和 CHD 风险之间的关系。
受试者/方法：我们通过问卷在基线时（年龄 45-74 岁）对 85293 名日本受试者进行了研究（1995 年和 1998 年分别为队列 I 和 II），他们在这两个时间点均无心血管疾病或癌症。队列 I 和 II 的参与者分别随访至 2009 年底和 2010 年底。膳食镁摄入量通过 138 项食物频率问卷进行估计。
经过 1305738 人年的随访，记录到 4110 例中风和 1283 例 CHD。多变量调整后的 CHD 风险比（HR，95%置信区间，95%CI）为，男性第 4 和第 5 五分位数膳食镁摄入量分别为 0.70（0.50-0.99）和 0.66（0.44-0.97）（趋势 P 值=0.036），女性第 3 五分位数为 0.61（0.39-0.96）（趋势 P 值=0.241），与男性和女性最低五分位数相比。我们没有观察到男性和女性中更高的膳食镁摄入量与中风发病率降低有关。
更高的膳食镁摄入量与日本男性 CHD 风险降低相关。
