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The STATs of cancer--new molecular targets come of age.

作者信息

Yu Hua, Jove Richard

机构信息

Immunology Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, 33612, USA.

出版信息

Nat Rev Cancer. 2004 Feb;4(2):97-105. doi: 10.1038/nrc1275.

DOI:10.1038/nrc1275
PMID:14964307
Abstract
摘要

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The STATs of cancer--new molecular targets come of age.癌症中的信号转导和转录激活因子——新的分子靶点走向成熟。
Nat Rev Cancer. 2004 Feb;4(2):97-105. doi: 10.1038/nrc1275.
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[STAT pathway of the intracellular signaling].[细胞内信号传导的STAT通路]
Zh Evol Biokhim Fiziol. 2000 Nov-Dec;36(6):504-8.
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STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.信号转导和转录的关键介质——信号转导及转录激活蛋白:从信号转导及转录激活蛋白5中获得的经验教训
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Activation of STAT proteins and growth control.信号转导和转录激活因子(STAT)蛋白的激活与生长调控
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Stat3 regulates genes common to both wound healing and cancer.信号转导与转录激活因子3(Stat3)调控伤口愈合和癌症共有的基因。
Oncogene. 2005 May 12;24(21):3397-408. doi: 10.1038/sj.onc.1208469.
6
Differential expression of signal transducers and activators of transcription during human adipogenesis.人脂肪生成过程中转录信号转导子和激活子的差异表达
Biochem Biophys Res Commun. 2001 Mar 9;281(4):907-12. doi: 10.1006/bbrc.2001.4460.
7
Differential function of STAT5 isoforms in head and neck cancer growth control.信号转导和转录激活因子5(STAT5)亚型在头颈部癌生长控制中的差异功能
Oncogene. 2002 Apr 25;21(18):2846-53. doi: 10.1038/sj.onc.1205385.
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The role of STATs in transcriptional control and their impact on cellular function.信号转导和转录激活因子(STATs)在转录调控中的作用及其对细胞功能的影响。
Oncogene. 2000 May 15;19(21):2468-73. doi: 10.1038/sj.onc.1203476.
9
Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation.STAT基因表达的实验调控揭示了STAT5参与白细胞介素-4驱动的细胞增殖。
Biol Chem. 2001 Feb;382(2):343-51. doi: 10.1515/BC.2001.041.
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New revelations about the role of STATs in stature.关于信号转导和转录激活因子(STATs)在身高方面作用的新发现。
N Engl J Med. 2003 Sep 18;349(12):1110-2. doi: 10.1056/NEJMp038134.

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Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit treatment naïve and therapy resistant forms ovarian cancer.来司替尼的抗肿瘤活性集中于JAK/STAT信号传导,以抑制未经治疗和对治疗耐药的卵巢癌形式。
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ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma.ACK1凝聚物促进肺鳞状细胞癌中的STAT5信号传导。
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assessment of BBI608 in 2D and 3D culture models for drug repositioning in oral squamous cell carcinoma.在二维和三维培养模型中评估BBI608用于口腔鳞状细胞癌的药物重新定位
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Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development.白细胞介素-6(IL-6)和信号转导与转录激活因子3(STAT3)的过表达可能为绵羊肺腺癌的发展提供新的见解。
BMC Vet Res. 2025 Jan 20;21(1):29. doi: 10.1186/s12917-024-04429-6.