Zhang Lei, Guo Wei, Lu Na, Tian Yuqing, Yang Jinghua, Wang Liang
Research Center of Traditional Chinese Medicine and Clinical Pharmacy, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Medicine (Baltimore). 2025 Jul 25;104(30):e43476. doi: 10.1097/MD.0000000000043476.
Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family, is a pivotal player in multiple cellular processes including proliferation, migration, differentiation, angiogenesis, programmed cell death, inflammatory response, and immune activation. As a transcription factor, the regulation of STAT3 activity is incredibly complicated as it is implicated signaling pathways in many distinct types of cells and under a diverse array of conditions. The activation of STAT3 commonly depends on the phosphorylation of specific residues in response to numerous growth factors and cytokines. With the discovery of STAT3 mediating gene expression in the absence of tyrosine/serine phosphorylation, a growing number of investigations related to unphosphorylated signal transducer and activator of transcription 3 (U-STAT3) demonstrated that U-STAT3 possess distinct features in regulation of gene expression. Herein, we summarize the current research progress in the roles of U-STAT3 in transcription and try to provide a basis for better understanding the complicated STAT3 activity regulation and its diverse functions.
信号转导与转录激活因子3（STAT3）是STAT家族的一员，在多种细胞过程中起着关键作用，包括增殖、迁移、分化、血管生成、程序性细胞死亡、炎症反应和免疫激活。作为一种转录因子，STAT3活性的调节极其复杂，因为它涉及许多不同类型细胞在多种条件下的信号通路。STAT3的激活通常依赖于特定残基的磷酸化，以响应多种生长因子和细胞因子。随着在酪氨酸/丝氨酸未磷酸化情况下STAT3介导基因表达的发现，越来越多与未磷酸化信号转导与转录激活因子3（U-STAT3）相关的研究表明，U-STAT3在基因表达调控中具有独特的特征。在此，我们总结了U-STAT3在转录作用方面的当前研究进展，并试图为更好地理解复杂的STAT3活性调节及其多样功能提供依据。
