Basu S K, Srinivasan M N, Chuttani K, George S
Radiation Biology Division, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Strahlenther Onkol. 1992 Jul;168(7):427-31.
Radioprotective efficiency of the combination of 5-hydroxy-L-tryptophan (5-HTP, 100 mg/kg) with 2-aminoethylisothiuronium bromide hydrobromide (AET, 20 mg/kg) in protecting splenic tissue following 8 Gy whole-body gamma radiation (WBGR) has been studied in adult male Sprague Dawley rats. Loss in splenic weight, splenic cells and DNA was observed following & Gy WBGR, which was modified significantly in 5-HTP+AET (ip) pretreated group. The study further showed that pre-treatment with this formulation led to an increased superoxide dismutase (SOD) activity and a decrease in lactate/pyruvate ratio in the cytosol fraction of the spleen.
在成年雄性斯普拉格-道利大鼠中，研究了5-羟基-L-色氨酸（5-HTP，100毫克/千克）与氢溴酸2-氨基乙基异硫脲（AET，20毫克/千克）联合使用对8 Gy全身γ射线照射（WBGR）后脾脏组织的辐射防护效果。8 Gy WBGR后观察到脾脏重量、脾细胞和DNA的损失，而在5-HTP+AET（腹腔注射）预处理组中这些损失得到了显著改善。该研究进一步表明，用这种制剂预处理可导致脾脏胞质部分的超氧化物歧化酶（SOD）活性增加，乳酸/丙酮酸比值降低。
