Eissa Maha M, Allam Sonia R, El-Azzouni Mervat Z, Maged Hala R, Dessouky Iman S
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
J Egypt Soc Parasitol. 2003 Aug;33(2):541-60.
The autoclaved cercarial vaccine (ACV) which is a special type of killed vaccine has been reported to induce experimental high level of homologous protective immunity. This study was to adjust the dose and to assess vaccine safety, longevity and stability as well as the possibility of transplacental transmission of immune response from pregnant mice to their offspring. The results showed that two doses of the lowest most effective concentration of ACV that achieved the high percentage reduction of worm burden is safe as demonstrated by absence of any local or systemic side effects, normal blood picture and normal liver and kidney function tests. ACV is stable when kept either at 4 degrees C for six months or at -35 degrees C for up to 12 months and it offered considerable duration of longevity. Offspring of vaccinated mothers didn't show any signs of protection against challenge infection.
已报道作为一种特殊类型的灭活疫苗的高压灭菌尾蚴疫苗（ACV）可诱导高水平的实验性同源保护性免疫。本研究旨在调整剂量并评估疫苗的安全性、有效期和稳定性，以及免疫反应从怀孕小鼠经胎盘传递给其后代的可能性。结果表明，两剂达到蠕虫负荷高百分比降低的最低最有效浓度的ACV是安全的，这表现为无任何局部或全身副作用、血常规正常以及肝肾功能测试正常。ACV在4℃保存6个月或在-35℃保存长达12个月时是稳定的，并且具有相当长的有效期。接种疫苗的母亲的后代未表现出任何针对攻击感染的保护迹象。
