Volod'ko N V, Derbeneva O A, Uinuk-ool T S, Sukernik R I
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Genetika. 2003 Dec;39(12):1710-8.
Variability of the HLA class II genes (alleles of the DRB1, DQA1, and DQB1 loci) was investigated in a sample of Aleuts of the Commanders (n = 31), whose ancestors inhabited the Commander Islands for many thousand years. Among 19 haplotypes revealed in Aleuts of the Commanders, at most eight were inherited from the native inhabitants of the Commander Islands. Five of these haplotypes (DRB10401-DQA10301-DQB10301, DRB11401-DQA10101-DQB10503, DRB10802-DQA10401-DQB10402, DRB11101-DQA10501-DQB10301, and DRB11201-DQA10501-DQB1*0301) were typical of Beringian Mongoloids, i.e., Coastal Chukchi and Koryaks, as well as Siberian and Alaskan Eskimos. Genetic contribution of the immigrants to the genetic pool of proper Aleuts constituted about 52%. Phylogenetic analysis based on Transberingian distribution of the DRB1 allele frequencies favored the hypothesis on the common origin of Paleo-Aleuts, Paleo-Eskimos, and the Indians from the northwestern North America, whose direct ancestors survived in Beringian/southwestern Alaskan coastal refugia during the late Ice Age.
对指挥官群岛阿留申人样本（n = 31）的人类白细胞抗原II类基因（DRB1、DQA1和DQB1基因座的等位基因）变异性进行了研究，其祖先在指挥官群岛居住了数千年。在指挥官群岛阿留申人所揭示的19种单倍型中，最多有8种是从指挥官群岛的原住民那里遗传而来的。其中5种单倍型（DRB10401 - DQA10301 - DQB10301、DRB11401 - DQA10101 - DQB10503、DRB10802 - DQA10401 - DQB10402、DRB11101 - DQA10501 - DQB10301和DRB11201 - DQA10501 - DQB1*0301）是白令海蒙古人种所特有的，即沿海楚科奇人和科里亚克人，以及西伯利亚和阿拉斯加爱斯基摩人。移民对纯正阿留申人基因库的遗传贡献约为52%。基于DRB1等位基因频率的跨白令海分布的系统发育分析支持了古阿留申人、古爱斯基摩人和北美西北部印第安人有着共同起源的假说，他们的直系祖先在末次冰期期间在白令海/阿拉斯加西南部沿海避难所中存活了下来。
