Department of Immunology, University Complutense, School of Medicine, Madrid, Spain.
Department of Immunology, University Complutense, School of Medicine, Madrid, Spain.
Hum Immunol. 2019 Sep;80(9):631-632. doi: 10.1016/j.humimm.2019.07.295. Epub 2019 Jul 23.
HLA-A, -B, -C and -DRB1 alleles and haplotypes have been studied in a group of Aleuts from Bering Island (Commander Islands, Russia). Many of their ancestors were original from other Aleutian Islands, like Attu and Atka Islands (USA) and may have had a low degree of admixture with Russians. HLA haplotypes are found to be specific and quite different from other First North America Inhabitants (including Amerindians, Na-Dene and Eskimo), as it was previously shown in a less numerous Aleut population. HLA-A*24:02 is found in a very high frequency; this character is shared by Pacific and Amerindian populations. In conclusion, HLA, other genetic markers, anthropological and linguistic traits make Aleuts to be different from First America Inhabitants and closer to Europeans and Asians: specifically Aleut relatedness has been found with Scandinavian Saami (Lapps) and Finns and Baikal Lake area Buryats, where all of them may have initialing being originated.
已在白令岛（俄罗斯的千岛群岛）的一群阿留申人（Aleuts）中研究了 HLA-A、-B、-C 和-DRB1 等位基因和单倍型。他们的许多祖先都来自于其他阿留申群岛，如阿图岛和阿特卡岛（美国），并且可能与俄罗斯人有一定程度的混合。与之前在人数较少的阿留申人群中所显示的情况一样，发现 HLA 单倍型是特定的，与其他北美原住民（包括美洲原住民、纳-德内语族和爱斯基摩人）有很大的不同。HLA-A*24:02 以非常高的频率出现；这一特征是太平洋和美洲原住民人群所共有的。总之，HLA、其他遗传标记、人类学和语言学特征使阿留申人与北美原住民不同，而与欧洲人和亚洲人更为接近：具体来说，已经发现与斯堪的纳维亚萨米人（拉普人）和芬兰人以及贝加尔湖地区的布里亚特人有关，他们可能都起源于初始地。
