Shih I-L, Van Y-T, Shen M-H
Department of Environmental Engineering, Da-Yeh University, Chang-Hwa, Taiwan 51505, Republic of China.
Mini Rev Med Chem. 2004 Feb;4(2):179-88. doi: 10.2174/1389557043487420.
This review article deals with the synthesis, physiochemical properties, and potential biomedical applications of two homo-poly amino acids. Poly-alpha-glutamic acid (alpha-PGA) and poly-alpha-lysine (alpha-PL) were synthesized by chemical synthesis. poly-gamma-glutamic acid (gamma-PGA) and poly-epsilon-lysine (epsilon-PL) were naturally occurring bio-materials that were produced by microbial fermentation. Poly(glutamic acid) (PGA) and poly(lysine) (PL) are water soluble, biodegradable, edible and nontoxic toward humans and the environment. As a result, they are suitable for various applications and have recently attracted considerable interest of the chemical industry. The distinguished features of PGA and PL also make them promising candidates for biomedical applications. The applications of PGA and PL in the areas of biomedical materials, drug delivery carriers and biological adhesives have been studied extensively and will be discussed in this review.
这篇综述文章探讨了两种同聚氨基酸的合成、理化性质及潜在的生物医学应用。聚-α-谷氨酸（α-PGA）和聚-α-赖氨酸（α-PL）通过化学合成法制备。聚-γ-谷氨酸（γ-PGA）和聚-ε-赖氨酸（ε-PL）是通过微生物发酵产生的天然生物材料。聚谷氨酸（PGA）和聚赖氨酸（PL）具有水溶性、可生物降解、可食用且对人类和环境无毒的特点。因此，它们适用于各种应用，最近已引起化学工业的广泛关注。PGA和PL的显著特性也使其成为生物医学应用的有前景的候选材料。PGA和PL在生物医学材料、药物递送载体和生物粘合剂领域的应用已得到广泛研究，并将在本综述中进行讨论。
