Buescher Joerg M, Margaritis Argyrios
Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Crit Rev Biotechnol. 2007 Jan-Mar;27(1):1-19. doi: 10.1080/07388550601166458.
This review article provides an updated critical literature review on the production and applications of Polyglutamic Acid (PGA). alpha-PGA is synthesized chemically, whereas gamma-PGA can be produced by a number of microbial species, most prominently various Bacilli. Great insight into the microbial formation of gamma-PGA has been gained thanks to the development of molecular biological techniques. Moreover, there is a great variety of applications for both isoforms of PGA, many of which have not been discovered until recently. These applications include: wastewater treatment, food products, drug delivery, medical adhesives, vaccines, PGA nanoparticles for on-site drug release in cancer chemotherapy, and tissue engineering.
这篇综述文章提供了关于聚谷氨酸（PGA）生产与应用的最新批判性文献综述。α-PGA通过化学合成，而γ-PGA可由多种微生物产生，其中最主要的是各种芽孢杆菌。由于分子生物学技术的发展，人们对γ-PGA的微生物形成有了深入了解。此外，PGA的两种异构体都有多种应用，其中许多直到最近才被发现。这些应用包括：废水处理、食品、药物递送、医用胶粘剂、疫苗、用于癌症化疗现场药物释放的PGA纳米颗粒以及组织工程。
