Li Ya-jie, Zhang Li-ying, Luo Bing-de, Li Yi-lei, Lin Ni
Department of Nursing, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Feb;24(2):152-4.
To observe the changes in rectal temperature (Tr) after immediate cooling therapy for Wistar rats with superficial second-degree scald burn in hot and humid environment, and evaluate the effect of the dressing material for cooling.
Twenty-four Wistar rats were randomly divided into 4 groups (n=6), namely normal temperature control (NTC), normal temperature cooling therapy (NTCT), hot and humid control (HHC), and hot and humid cooling therapy (HHCT) groups. Superficial second-degree scald burns were induced in the rats, followed by interventions with cooling therapy in the two therapy groups at dry bulb temperature (Tdb) of 35.33+/-0.35 degrees Celsius with relative humidity of 70.81%+/-1.38%, whereas the two control groups were treated at Tdb of 26.33+/-1.29 degrees Celsius with relative humidity of 71.05%+/-4.57% without dressing for cooling therapy. The exposure time of each group was 120 min, and the Tr was recorded every 20 min.
On the basis of comparisons between the measurements taken at 7 different time points, we found that the Tr of the rats was elevated in hot and humid environment (P<0.001) and decreased when cooling therapy was applied (P<0.001). Interactions between the environmental temperature and cooling therapy were noted in their influence on Tr (P=0.003). As the exposure time was prolonged, Tr slowly decreased in NTC group, mildly fluctuated in NTCT group, but elevated in HHC and HHCT groups with gradual increase of the differences between the measurements taken at the same time point.
Application of the dressing material on the abdomen for cooling therapy can efficiently lower the Tr, which may prevent the progression of the heat injury.
观察湿热环境下浅Ⅱ度烫伤的Wistar大鼠即刻冷疗后直肠温度（Tr）的变化，评价冷疗敷料的效果。
将24只Wistar大鼠随机分为4组（n = 6），即常温对照组（NTC）、常温冷疗组（NTCT）、湿热对照组（HHC）和湿热冷疗组（HHCT）。对大鼠进行浅Ⅱ度烫伤，然后在干球温度（Tdb）为35.33±0.35摄氏度、相对湿度为70.81%±1.38%的条件下，对两个治疗组进行冷疗干预，而两个对照组在Tdb为26.33±1.29摄氏度、相对湿度为71.05%±4.57%的条件下不进行冷疗敷料处理。每组暴露时间为120分钟，每20分钟记录一次Tr。
通过对7个不同时间点测量值的比较，我们发现大鼠的Tr在湿热环境中升高（P < 0.001），在进行冷疗时降低（P < 0.001）。环境温度和冷疗之间的相互作用对Tr有影响（P = 0.003）。随着暴露时间的延长，NTC组的Tr缓慢下降，NTCT组轻度波动，而HHC组和HHCT组的Tr升高，同一时间点测量值之间的差异逐渐增大。
在腹部使用敷料进行冷疗可有效降低Tr，这可能预防热损伤的进展。
