[冷却疗法对湿热环境下二度烫伤大鼠心率及平均动脉压的影响]

[Effect of cooling therapy on the heart rate and mean arterial pressure of rats with the second-degree scald burn in hot and humid environment].

作者信息

Li Ya-jie, Zhang Li-ying, Luo Bing-de, Li Yi-lei, Lin Ni

机构信息

Department of Nursing, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

出版信息

Di Yi Jun Yi Da Xue Xue Bao. 2004 Mar;24(3):314-6.

PMID:15041549

Abstract

OBJECTIVE

To observe the changes of heart rate (HR) and mean arterial pressure MAP after immediate cooling therapy (ICT) in rats with superficial second-degree scald burn in hot and humid environment, and assess the effect of the cooling dressing materials.

METHODS

Twenty-four Wistar rats were randomized equally into 4 groups including normal temperature control (NTC) group, normal temperature cooling therapy (NCT) group, hot and humid control (HHC) group and hot and humid cooling therapy (HCT) group. Different interventions were applied as indicated in the rats with superficial second-degree scald burn, with the dry bulb temperature Tdb at 26.33+/-1.29 degrees celsius; and relative humidity (rh) of 71.05%+/-4.57% for two normal temperature groups, and Tdb at 35.33+/-0.35 degrees Celsius; and rh of 70.81%+/-1.38% for the two hot and humid groups. The exposure time was 120 min in NCT and HCT groups, and the HR and MAP were measured every 20 min.

RESULTS

MAP is not influenced by environmental temperature and the cooling therapy (P>0.05), whereas HR was higher in HHC than in NTC group and also in HCT than in NCT group (P=0.003), lower in HCT and NCT groups than in HHC and NTC groups (P=0.002), respectively. HR did not undergo any significant changes during the observation in the 4 groups (P>0.05). HR was higher in HHC and HCT than in NTC and NCT groups at 65, 85, 105 and 125 min after the burns, but compared with the two control groups, cooling therapy decreased HR at 5, 25, 45 and 85 min.

CONCLUSION

Cooling therapy does not affect MAP but efficiently decreases HR, which may prevent further heat injury.

摘要

目的

观察湿热环境下浅Ⅱ度烫伤大鼠即刻冷疗（ICT）后心率（HR）和平均动脉压（MAP）的变化，并评估冷疗敷料材料的效果。

方法

将24只Wistar大鼠随机均分为4组，包括常温对照组（NTC）、常温冷疗组（NCT）、湿热对照组（HHC）和湿热冷疗组（HCT）。对浅Ⅱ度烫伤大鼠进行不同干预，两个常温组的干球温度（Tdb）为26.33±1.29摄氏度，相对湿度（rh）为71.05%±4.57%；两个湿热组的Tdb为35.33±0.35摄氏度，rh为70.81%±1.38%。NCT组和HCT组的暴露时间为120分钟，每20分钟测量一次HR和MAP。

结果

MAP不受环境温度和冷疗的影响（P>0.05），而HHC组的HR高于NTC组，HCT组的HR也高于NCT组（P=0.003），HCT组和NCT组的HR分别低于HHC组和NTC组（P=0.002）。4组在观察期间HR均无显著变化（P>0.05）。烫伤后65、85、105和125分钟时，HHC组和HCT组的HR高于NTC组和NCT组，但与两个对照组相比，冷疗在5、25、45和85分钟时降低了HR。