Markus H S
Clinical Neuroscience, St George's Hospital Medical School, London, UK.
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):353-61. doi: 10.1136/jnnp.2003.025825.
Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, but all result in a disruption of cerebral blood flow with subsequent tissue damage. This review covers the mechanisms responsible for regulation of the normal cerebral circulation, and how they are disrupted in disease states. A central concept in treating patients with acute ischaemic stroke is the existence of an ischaemic penumbra of potentially salvageable tissue, and the evidence for its existence in humans is reviewed.
中风是一种由多种疾病机制引起的异质性综合征，但所有这些机制都会导致脑血流中断，继而造成组织损伤。本综述涵盖了负责调节正常脑循环的机制，以及它们在疾病状态下是如何被破坏的。治疗急性缺血性中风患者的一个核心概念是存在潜在可挽救组织的缺血半暗带，本文将对其在人类中存在的证据进行综述。
