扩散张量磁共振成像显示帕金森病大脑的早期病理变化。
Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI.
作者信息
Yoshikawa K, Nakata Y, Yamada K, Nakagawa M
机构信息
Department of Neurology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):481-4. doi: 10.1136/jnnp.2003.021873.
OBJECTIVE
To determine whether the fractional anisotropy (FA) of magnetic resonance diffusion tensor imaging is decreased in the nigrostriatal projection in parkinsonian patients.
METHODS
FA values were compared in the extrapyramidal system of 12 patients with Parkinson's disease and eight age matched normal controls.
RESULTS
Patients with Parkinson's disease had significantly decreased FA in the region of interest along a line between the substantia nigra and the lower part of the putamen/caudate complex, in which most of the nigrostriatal dopaminergic neurones are included. Loss of FA in this region was obvious even during the early clinical stages of Parkinson's disease.
CONCLUSIONS
Assuming that the loss of FA parallels the neuronal change in the brain, the results are consistent with the view that more than half the dopaminergic neurones in the nigrostriatal projection are lost before the onset of Parkinson's disease. Close comparison of FA in the basal ganglia may contribute to the early diagnosis of Parkinson's disease.
目的
确定帕金森病患者黑质纹状体投射中磁共振扩散张量成像的分数各向异性（FA）是否降低。
方法
比较了12例帕金森病患者和8例年龄匹配的正常对照者锥体外系的FA值。
结果
帕金森病患者在黑质与壳核/尾状核复合体下部之间的连线上的感兴趣区域FA显著降低，该区域包含了大部分黑质纹状体多巴胺能神经元。即使在帕金森病临床早期，该区域的FA丢失也很明显。
结论
假设FA的丢失与大脑中的神经元变化平行，结果与以下观点一致，即黑质纹状体投射中超过一半的多巴胺能神经元在帕金森病发病前就已丢失。基底节区FA的密切比较可能有助于帕金森病的早期诊断。
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