Tufail Muhammad, Jiang Can-Hua, Li Ning
Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Institute of Oral Precancerous Lesions, Central South University, Changsha, 410008, China.
Mil Med Res. 2025 Feb 11;12(1):7. doi: 10.1186/s40779-025-00595-2.
Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have the ability to evade detection and treatment, leading to relapse. This review emphasizes the urgent need to comprehend tumor dormancy and its implications for cancer recurrence. Despite notable advancements, significant gaps remain in our understanding of the mechanisms underlying dormancy and the lack of reliable biomarkers for predicting relapse. This review provides a comprehensive analysis of the cellular, angiogenic, and immunological aspects of dormancy. It highlights the current therapeutic strategies targeting dormant cells, particularly combination therapies and immunotherapies, which hold promise in preventing relapse. By elucidating these mechanisms and proposing innovative research methodologies, this review aims to deepen our understanding of tumor dormancy, ultimately facilitating the development of more effective strategies for preventing cancer recurrence and improving patient outcomes.
由肿瘤休眠现象驱动的癌症复发是肿瘤学中一项艰巨的挑战。休眠癌细胞有能力逃避检测和治疗，从而导致复发。本综述强调迫切需要了解肿瘤休眠及其对癌症复发的影响。尽管取得了显著进展，但我们对休眠潜在机制的理解仍存在重大差距，并且缺乏预测复发的可靠生物标志物。本综述对休眠的细胞、血管生成和免疫方面进行了全面分析。它强调了当前针对休眠细胞的治疗策略，特别是联合疗法和免疫疗法，这些疗法在预防复发方面具有前景。通过阐明这些机制并提出创新的研究方法，本综述旨在加深我们对肿瘤休眠的理解，最终促进开发更有效的预防癌症复发和改善患者预后的策略。
