Agarwal Ashok, Ranganathan Pavithra, Kattal Namita, Pasqualotto Fabio, Hallak Jorge, Khayal Saba, Mascha Edward
Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Fertil Steril. 2004 Feb;81(2):342-8. doi: 10.1016/j.fertnstert.2003.07.021.
To examine the outcome of assisted reproduction techniques (ART) using cryopreserved semen from patients with cancer.
Prospective.
Therapeutic semen banking program at a tertiary healthcare center.
PATIENT(S): Twenty-nine men with cancer who cryopreserved their sperm before treatment at our facility from 1982 to 2001 and withdrew their samples for assisted reproduction (IUI, IVF, or intracytoplasmic sperm injection [ICSI]).
INTERVENTION(S): Sperm bank records were used to identify the patients. Information on fertility potential indices was obtained from medical records and through interviews. Of the 29 patients, 9 had testicular cancer, 12 had Hodgkin's disease, and 8 had other types of cancer.
MAIN OUTCOME MEASURE(S): Pregnancy and live births.
RESULT(S): A total of 87 ART cycles (42 IUI, 26 IVF, and 19 ICSI) was performed. Of those cycles, 18.3% resulted in pregnancy (7% IUI, 23% IVF, and 37% ICSI), and 75% of the pregnancies resulted in a live birth (100% IUI, 83% IVF, and 57% ICSI). There was no significant difference in the outcomes when the results were stratified by type of ART and malignancy. None of the 11 infants who were born had congenital anomalies.
CONCLUSION(S): Our findings emphasize the need for physicians to discuss the issue of semen cryopreservation with all men of reproductive age who have cancer before antineoplastic therapy is started.
研究使用癌症患者冷冻保存精液的辅助生殖技术（ART）的结果。
前瞻性研究。
一家三级医疗中心的治疗性精液库项目。
1982年至2001年期间在我们机构接受治疗前冷冻保存精子并提取样本用于辅助生殖（宫内人工授精、体外受精或卵胞浆内单精子注射[ICSI]）的29名癌症男性。
利用精液库记录识别患者。从病历和访谈中获取生育潜力指标信息。29名患者中，9名患有睾丸癌，12名患有霍奇金病，8名患有其他类型癌症。
妊娠和活产。
共进行了87个ART周期（42个宫内人工授精、26个体外受精和19个卵胞浆内单精子注射）。在这些周期中，18.3%导致妊娠（宫内人工授精7%、体外受精23%、卵胞浆内单精子注射37%），75%的妊娠分娩出活产婴儿（宫内人工授精100%、体外受精83%、卵胞浆内单精子注射57%）。按ART类型和恶性肿瘤分层后的结果无显著差异。出生的11名婴儿均无先天性异常。
我们的研究结果强调，医生需要在开始抗肿瘤治疗前，与所有患有癌症的育龄男性讨论精液冷冻保存问题。
