Saijo Yasuaki, Sata Fumihiro, Yamada Hideto, Kondo Tomoko, Kato Emi Hirayama, Kishi Reiko
Department of Public Heath, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Fertil Steril. 2004 Feb;81(2):374-8. doi: 10.1016/j.fertnstert.2003.06.023.
To investigate the relationships between recurrent pregnancy loss and single nucleotide polymorphisms (-634C-->G and -174G-->C genotypes) in the promoter region of the interleukin (IL)-6 gene in the Japanese population.
A case-control study.
Obstetrics and gynecology department of a university hospital.
PATIENT(S): Cases were 76 women with recurrent pregnancy loss; controls were 93 fertile women.
INTERVENTION(S): Determination of IL-6 promoter gene polymorphisms performed by polymerase chain reaction and gel electrophoresis.
MAIN OUTCOME MEASURE(S): Frequency and distribution of the promoter region of the IL-6 gene allele.
There was a significant difference in the -634C-->G genotype frequency (CC vs. CG/GG) between women with recurrent pregnancy loss and controls. The risk of recurrent pregnancy loss was lower in the carriers of the G allele than in women with the wild type (CC) (odds ratio = 0.46; 95% confidence interval = 0.24-0.91). On the other hand, we did not detect any carrier of -174C among the 169 subjects.
CONCLUSION(S): The results suggest that, in the Japanese population, women carrying the -634G allele of the IL-6 gene might have a decreased risk of recurrent pregnancy loss.
探讨日本人群中复发性流产与白细胞介素（IL）-6基因启动子区域单核苷酸多态性（-634C→G和-174G→C基因型）之间的关系。
病例对照研究。
某大学医院妇产科。
病例为76例复发性流产女性；对照为93例有生育能力的女性。
通过聚合酶链反应和凝胶电泳测定IL-6启动子基因多态性。
IL-6基因启动子区域等位基因的频率和分布。
复发性流产女性与对照之间-634C→G基因型频率（CC与CG/GG）存在显著差异。G等位基因携带者复发性流产的风险低于野生型（CC）女性（比值比=0.46；95%置信区间=0.24-0.91）。另一方面，在169名受试者中未检测到-174C的携带者。
结果表明，在日本人群中，携带IL-6基因-634G等位基因的女性复发性流产风险可能降低。
