Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA.
J Reprod Immunol. 2011 Jan;88(1):48-52. doi: 10.1016/j.jri.2010.06.159. Epub 2010 Oct 24.
Vascular endothelial growth factor-A (VEGFA) is normally expressed at high levels in the human placenta, and lower levels have been observed in placental tissue of women with recurrent pregnancy loss. The objective of this study was to determine if genetic polymorphisms in the VEGFA gene associated with altered gene expression play a role in some cases of recurrent pregnancy loss (RPL). A case-control study of 99 women with RPL and 181 fertile controls was performed evaluating four common VEGFA polymorphisms associated with altered gene expression (-2578 C/A, -1154 G/A, -634 G/C, and +936 C/T). The allele frequency of the -2578 A allele was lower among women with RPL compared to fertile controls (0.39 vs. 0.48, p=0.049), while the allele frequency of the -634 C allele was higher among women with RPL compared to fertile controls (0.39 vs. 0.29, p=0.020). Women with RPL and controls had similar allele frequencies for the -1154 and +936 minor alleles. We conclude that some allelic polymorphisms associated with altered expression of VEGFA are more common among women with RPL compared to fertile controls.
血管内皮生长因子-A（VEGFA）在人类胎盘组织中高水平表达，而在反复妊娠丢失（RPL）妇女的胎盘组织中观察到较低水平。本研究旨在确定与改变基因表达相关的 VEGFA 基因中的遗传多态性是否在某些 RPL 病例中发挥作用。对 99 名 RPL 妇女和 181 名生育力对照组进行病例对照研究，评估与改变基因表达相关的四个常见 VEGFA 多态性（-2578 C/A、-1154 G/A、-634 G/C 和 +936 C/T）。与生育对照组相比，RPL 妇女中 -2578A 等位基因的等位基因频率较低（0.39 比 0.48，p=0.049），而 RPL 妇女中 -634C 等位基因的等位基因频率较高（0.39 比 0.29，p=0.020）。与生育对照组相比，RPL 妇女和对照组的 -1154 和 +936 次要等位基因的等位基因频率相似。我们得出结论，与改变 VEGFA 表达相关的某些等位基因多态性在 RPL 妇女中比在生育对照组中更为常见。
