Chauvierre Cedric, Marden M C Michael C, Vauthier Christine, Labarre Denis, Couvreur Patrick, Leclerc Liliane
Laboratoire de Physico-Chimie, Faculté de Pharmacie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université Paris-Sud XI, 5 rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Biomaterials. 2004 Jul;25(15):3081-6. doi: 10.1016/j.biomaterials.2003.09.097.
A new generation of drug delivery systems based on heparin-poly(isobutylcyanoacrylate) copolymers has been developed to carry hemoglobin. These copolymers spontaneously form, in water, nanoparticles with a ciliated surface of heparin. These nanoparticles maintain the heparin antithrombotic properties and inhibit complement activation. One ml of nanoparticle suspension can be loaded with up to 2.1mg of hemoglobin, which preserves its ligand binding capacity. This work constitutes the first demonstration of hemoglobin loaded on nanoparticle surface, rather than being encapsulated. With a size of 100 nm, these drug delivery systems make suitable tools in the treatment of thrombosis oxygen deprived pathologies.
基于肝素-聚（异丁基氰基丙烯酸酯）共聚物的新一代药物递送系统已被开发用于携带血红蛋白。这些共聚物在水中自发形成具有肝素纤毛表面的纳米颗粒。这些纳米颗粒保持肝素的抗血栓特性并抑制补体激活。一毫升纳米颗粒悬浮液可负载多达2.1毫克的血红蛋白，且能保留其配体结合能力。这项工作首次证明了血红蛋白负载在纳米颗粒表面，而非被包裹在其中。这些药物递送系统尺寸为100纳米，是治疗血栓形成性缺氧疾病的合适工具。
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